So the LRRK2 enzyme, which is also known internationally by the name ... one of the active forms of vitamin B12, acts as an inhibitor of the kinase activity of LRRK2 in cultured cells and brain tissue ...

Cobalamin, also known as vitamin B12, helps facilitate a variety of enzyme-driven reactions. However, this type of "radical chemistry" is uncommon in known reactions where cobalamin is involved ...

One such essential nutrient is vitamin B12, which is scientifically known as cobalamin, which regulates some of the most important functions of the body. However, vitamin B12 is one such nutrient ...

This report describes an approach for trapping intermediates involved in the cobalamin biosynthetic pathway in their natural (free acid) form as enzyme-product complexes. CobJ, CobK and CobH were ...

Vitamin B12 plays a critical role in the metabolism of every cell in the body. It is converted into co-factors that aid the function of specific enzymes involved in DNA synthesis and regulation, lipid ...

AdoCbl is one of the active forms of vitamin B12 which inhibits kinase activity of LRRK2 enzyme and prevents the neurotoxicity in Hereditary Parkinson's in cultured cells of primary rodents and in ...