The PKU-associated enzyme deficiency was determined biochemically in the 1950s—long before the PAH-encoding gene was mapped to human chromosome 12 and cloned in 1983. Specifically, Dr. Willard ...
Instead, genome organization correlates with chromosomal abnormalities. Every cancerous lymphocyte Misteli's team examined contained translocations among chromosomes 12, 14, and 15. In normal primary ...
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