In the study, investigators utilized nanoscale imaging and sensing technologies along with modeling techniques developed at Northwestern to individually label and observe chromatin fibers ...

This was Chang’s motivation for developing a technique called ATAC-seq (assay for transposase-accessible chromatin)—in which DNA tags (acting as transposons) are enzymatically integrated into open ...

Varshavsky studied chromatin structure and wanted to develop new methods ... which they then amplify and label with a fluorescent dye. The scientists next hybridize the DNA to a microarray containing ...

His team grew cells in the presence of either unlabeled or deuterium-labeled lysine and purified chromatin from the deuterium-labeled nuclear extracts with a specific DNA bait or from the ...