Histones not only keep DNA organized, but also help regulate gene expression. How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell ...

So far, a number of histone variants have been found and localized to specific areas of chromatin. For instance, H2A.Z is a variant of H2A and is often enriched near relatively inactive gene ...

This process begins with their conversion into active metabolites, propionyl-CoA and butyryl-CoA, which are then used as cofactors in histone acylation. These modifications alter chromatin ...

Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes ... potential therapeutic approaches to silence its transcription. By focusing on chromatin-modifying enzymes ...

AC, acetylation; HDAC2, histone deacetylase 2; HIF-α ... HDACis enhance radiosensitivity by modulating genes involved in DNA repair and altering chromatin structure. 21 They also target specific HDAC ...

Novel technology enables discovery, which could help predict tumour recurrence Researchers from the Fred Hutch Cancer Centre, ...

Approximately 50% of chromosomes and chromatin is protein. These include histones, transcription factors, nuclear receptors, co-activators, co-repressors, histone modifying enzymes, nucleosome binding ...

But how exactly does COVID-19 remodel chromatin? One mechanism may be through epigenetic changes. The infected cells were missing an acetyl group—known as H3K27Ac—on their third histone that’s ...

ERIL provides MSK researchers with state-of-the-art epigenetics research resources and services to study cancer-associated changes in chromatin accessibility, DNA methylation, and histone ...

The fusion protein binds to the LacO domains (1), and incorporates the specialized centromeric histone CENP-A into and along neighboring chromatin (2). In turn, the region of CENP-A-containing ...