To achieve this packaging feat, DNA is wrapped around proteins to make chromatin fibers, and further condensed into tightly concertinaed loops. The formation and maintenance of these loops largely ...

“The chromatin change provides an unappreciated mechanism to ... In uninfected cells, a protein complex called cohesin encircles each domain, forming tight loops that bring each gene close to an ...

or proteins that load cohesin onto chromatin (Sherwood et al., 2010). In addition, mutations in cohesin are increasingly seen in cancer genome sequencing. These and other data point to an important ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...