As previously mentioned, chromatin is remodeled (and thus, nucleosome structure is altered) primarily through posttranslational modifications of histone proteins, which actually change the ...

Chromatin structure is highly complex and impressively ... The cumulative effects of these changes are various states of transcriptional control and the ability of eukaryotic cells to turn genes ...

Now, in a study published March 23 in Nature Microbiology, Li and colleagues reveal how the virus responsible for COVID-19 remodels chromatin, the complex of DNA and proteins that makes up chromosomes ...

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights ...

“This is the first study using this model of replicative senescence to define those higher-order three-dimensional chromatin changes,” said epigeneticist Peter Adams of the Cancer Research UK Beatson ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves.

Now, we aim to understand mechanisms of how these chromatin changes in these physiological contexts relate to specific responses in gene regulation. We aim to trace metabolite signaling to chromatin, ...

Preliminary data from Parse’s chromatin assay showing clustering of mouse brain nuclei based on DNA accessibility profiles. (Graphic: Business Wire) SEATTLE, March 04, 2025--(BUSINESS WIRE ...

In eukaryotes, genomic DNA is stored in the nucleus as nucleosomes, interacting with a set of proteins, forming a molecular complex called chromatin. The proper folding of the chromatin structure ...

This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to reveal mechanisms of disease. Our laboratory works at the intersection of three fields: ...