Each of our cells store their genetic information in the nucleus (genomic DNA) and mitochondria (mitochondrial DNA). A ...

Cyclic GMP-AMP synthase (cGAS), a critical mediator of innate immune responses, has recently been identified as a potential contributor to cardiac dysfunction. This study was aimed at ...

Chen’s discovery of cGAS, short for cyclic guanosine monophosphate-adenosine ... DNA is normally contained in the nucleus and mitochondria, so when it shows up where it doesn’t belong—like outside the ...

But it became increasingly clear that there was also a mechanism driving recognition of microbial DNA within the cytosol (cellular fluid outside the nucleus ... The cGAS-STING pathway begins ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

cGAS titration at 1 hour and 24 hours demonstrates the assay's oustanding signal stability. The signal stability seen here is crucial for HTS where the screen size can require significant more time.