Cellular senescence—an irreversible cell-cycle arrest coupled with the production of pro-inflammatory secretions known as ...

Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, ...

The mystery of how cancers build up resistance mechanisms and evade the treatments that should have destroyed them is a ...

How does a cell know when it’s been damaged? A molecular alarm, set off by mutated RNA and colliding ribosomes, signals ...

A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how ...

Despite being a cell cycle inhibitor, ... the team showed that removing the p21 gene stopped cells entering the sleeping state. This led to a higher level of DNA damage and increased cell death.

Researchers have taken a big step forward in the quest to regenerate the pancreatic beta-cells damaged by type 1 diabetes. Using FDA-approved drugs usually given to patients with rare cancers ...

A new stem cell therapy has repaired blinding damage to the cornea in 93% of patients in an early clinical trial. However, severe injuries, such as those caused by chemical burns or infections ...