In addition, we were unable to demonstrate immunoprecipitation of DAP12 or FcRγ together with CD18 in adherent neutrophils. Therefore, integrins are unlikely to associate directly with DAP12 or ...

CD11b-CD18 and CD49d-CD29 integrins 5. By activating endothelial cells with interleukin 1β (IL-1β) or tumor necrosis factor (TNF), we were able to maintain their adhesion to the monolayers ...

The β 2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2, which encodes CD18 ...

Subsequently, it was recognized that the process of aggregation and attachment of neutrophils to endothelial surfaces was mediated by a group of molecules called integrins and selectins and that ...

This mutation leads to the production of a defective protein called CD18, preventing leukocytes from traveling to infection sites and effectively fighting infections. Without treatment ...

A collaboration between three labs at UC San Francisco has resulted in an unprecedented look at a member of a vital and ubiquitous class of proteins called integrins (pronounced “INT-uh-grins”).

The Fagerholm group studies the role of leukocyte integrins in various immune reactions. We are interested in the in vivo roles and regulation of leukocyte beta2-integrins in a healthy and ...

A collaboration between three labs at UC San Francisco has resulted in an unprecedented look at a member of a vital and ubiquitous class of proteins called integrins (pronounced "INT-uh-grins").

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC ...