Part of the challenge of delivering treatments for Alzheimer's and other diseases linked to the brain is getting past the robust defenses the brain puts in place to protect itself.

But they also speed up development of a lethal wasting disease called cachexia. In mice, researchers have found that pairing keto with a corticosteroid prevents cachexia and increases survival.

We used these neuroscience tools in a mouse model of cancer cachexia to study the effects of the disease on the brain and motivation. We identified a small brain region called the area postrema th ...

However, after observing that mice with cachexia exhibited increased levels of IL-6 in their blood, followed by classical cachexia symptoms such as anorexia and dramatic weight loss, Li became ...

That’s because of cachexia, a condition in which impaired metabolism leads to muscle wasting and drastic weight loss (SN: 4/15/15). A new study in mice hints at a way to reverse the condition.

Cachexia is a metabolic syndrome characterized by the loss of body fat and muscle mass and affects about 50%–80% of cancer patients.The condition results in a deterioration in quality of life ...

Now, Li and a team of collaborators from four CSHL labs have found that blocking IL-6 from binding to neurons in a part of the brain called the area postrema (AP) prevents cachexia in mice.

Mice with lack of appetite and weight loss ... Some cancer patients can also develop a similar disorder called cancer cachexia, which comes from an impaired metabolism, that is similarly ...

We used these neuroscience tools in a mouse model of cancer cachexia to study the effects of the disease on the brain and motivation. We identified a small brain region called the area postrema ...

Perhaps most exciting, we found several ways to restore motivation in mice suffering from cancer cachexia—even when the cancer itself continued progressing. First, by genetically switching off ...