A cruel consequence of advanced cancer is the profound apathy many patients experience as they lose interest in ...

Researchers identified a direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer. In a mouse study, they describe a brain pathway that starts ...

OSU scientists created nanoparticles that deliver anti-inflammatory drugs across the blood-brain barrier, offering hope for ...

The fatigue and lack of motivation that many cancer patients experience near the end of life have been seen as the ...

The fatigue and lack of motivation that many cancer patients experience near the end of life have been seen as the unavoidable consequences of their declining physical health and extreme weight loss.

They found that as cachexia progresses, certain neurons release less and less dopamine. That’s the brain’s “feel-good” chemical. Screening for elevated immune system proteins in the brains and bodies ...

Researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, opening the door to potential new therapies for a range of conditions, including Alzheimer's disease ...

A study identifies a brain pathway linking inflammation to dopamine loss and apathy in cancer. Researchers found that IL-6 ...

Perhaps most exciting, we found several ways to restore motivation in mice suffering from cancer cachexia − even when the cancer itself continued progressing. First, by genetically switching off ...