CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

In a precedential opinion issued on Monday, the U.S. Court of Appeals for the Federal Circuit (CAFC) vacated and remanded a ...

Base-editing technologies along with AAV engineering not only help reduce costs but can also accelerate preclinical ...

In a new study published in Nature titled, “Custom CRISPR-Cas9 PAM variants via scalable ... adjacent motifs (PAMs), which initiate guide RNA pairing with the target site. In the case of ...

Beam Therapeutics and Verve Therapeutics have each built their lead candidates on a technique billed as a safer alternative ...

Researchers at Karolinska Institutet have developed a technique that enables efficient delivery of therapeutic proteins and ...

Researchers have developed a technique that enables efficient delivery of therapeutic proteins and RNA to cells. The method shows promising results in animal studies to deliver gene editors and ...

As part of the 10th Mediterranean Neuroscience Society Conference, we are excited to present this new collection of articles ...

The CRISPR/Cas9 system consists of the Cas9 endonuclease and a single-guide RNA (sgRNA). The sgRNA is designed to match the sequence of a specific genomic locus, directing the Cas9 protein to this ...

Researchers from the University of Eastern Finland, Aalto University and the University of Oulu have developed a new ...