AMX0114 is an antisense oligonucleotide made to prevent or slow the degeneration of axons, which is a key driver of ALS ...

The two researchers quickly homed in on a calpain known as calpain-5. They found that this enzyme undergoes rapid activation in the early stages of myoblast differentiation—a crucial process in ...

Amylyx Pharmaceuticals chief medical officer Camille Bedrosian said: “AMX0114 targets calpain-2, which is an important contributor to axonal degeneration and studied over decades of research as ...