Most drugs are metabolized by CYP3A enzymes, and variations in expression levels of these enzymes are believed to determine whether patients will have a positive or adverse drug response.

Concomitant strong or moderate CYP3A inducers: Avoid use with Nurtec ODT; may lead to loss of efficacy. Concomitant potent inhibitors of P-gp: Avoid another dose of Nurtec ODT within 48 hours.