The inactivation and clearance of the tricyclic antidepressant imipramine is dependent on CYP2D6 activity. First, CYP2C19 converts imipramine into the active metabolite desipramine, which is then ...

This study examined, for the first time, whether a high CYP2D6-CYP2C19 metabolic capacity combination increases the likelihood of suicidal intent severity in a large study cohort. Survivors of a ...

CYP2D6 structural variants were observed in 13 percent of patients. A majority of these structural variants (73 percent) are known to confer decreased or no CYP2D6 function.

Although CYP2D6*4 is the most prevalent nonfunctional allele, there are over 90 CYP2D6 polymorphic variants, and at least half of them affect enzymatic function. [203] ...

Tamoxifen itself doesn’t fight cancer. It must first be converted, or “metabolized,” into an active metabolite called endoxifen. CYP2D6 facilitates that crucial switch. For women with an inherited ...

The study showed that women lacking the CYP2D6 enzyme function (poor metabolizers) had an almost 2-fold increased risk of developing breast cancer, compared with women who had full CYP2D6 function ...

CYP2D6 is the key enzyme responsible for the generation of the potent tamoxifen metabolite, endoxifen. Multiple studies have examined the relationship of CYP2D6 status to breast cancer outcomes in ...

Of the 3 beta-blockers recommended for use in HF patients, 2 are metabolized by CYP2D6, “a highly polymorphic enzyme of the P450 family.” Because of this, these agents are subject to varying ...

The researchers found higher breast cancer event rates in patients with reduced or absent CYP2D6 function vs. extensive metabolism patients. "At 9 years of follow-up, the recurrence rates were 14. ...

The researchers found higher breast cancer event rates in patients with reduced or absent CYP2D6 function vs. extensive metabolism patients. "At 9 years of follow-up, the recurrence rates were 14. ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...

Evidence has emerged that the clinical benefit of tamoxifen is related to the functional status of the hepatic metabolizing enzyme cytochrome P450 2D6 (CYP2D6). CYP2D6 is the key enzyme responsible ...