Background: CXCR4 is over-expressed on > 75% of cancers and absent on most non-neoplastic cells. It is a G protein coupled receptor spanning the cell membrane with CXCL-12 as its ligand. It is ...

The chemokine CXCL12 and its receptor CXCR4 have been proposed as targets for the treatment of myocardial infarction. Results obtained by Ludwig-Maximilians-Universitaet in Munich researchers ...

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been ...

CXCR4 functions as an HIV co-receptor by the binding CD4 protein, allowing HIV to enter cells. As illustrated in the image below, gp120 on the HIV viral membrane is essential for infecting CD4 T ...

However, other clinical applications for CXCR4 inhibitors in addition to anti-HIV therapy have been considered, as the interaction between CXCR4 and its ligand SDF-1 is also involved in several ...

The CXCR4 mutation library was also used to map residues that participate in SDF-dependent signaling by monitoring CXCR4 function (calcium flux) in response to its cognate ligand SDF-1α (Figure 2B).

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been ...

The randomized, open-label, multicenter study is designed to assess whether GPC-100, a small molecule CXCR4 antagonist, can improve CD34+ hematopoietic stem cell mobilization from the bone marrow ...