For Dr Waiß, the high significance of CXCL13 levels in CSF and the readily available test to measure the concentration lead to a clear clinical benefit of the study, now published in the Journal ...

3'RNA sequencing was performed in 1,733 patients from the PETACC-8 trial and 1,248 patients from the IDEA-France trial. Four transcriptomic signatures were analyzed: T-cell and macrophage M2 ...

CXCL13-mediated recruitment of B cells could help predict response to immunotherapy Date: June 26, 2023 Source: University of California - Los Angeles Health Sciences Summary: ...

We found that chemokine CXCL13 was consistently overexpressed in tumor samples showing a 18-fold higher expression than autologous normal breast tissue. This finding was confirmed by gene-specific ...

Robust Anti-Tumor Efficacy: Engineered DCs expressing CD93, CD40L, and CXCL13 significantly reduced tumor weight and volume, namely up to 81.7% in humanized mouse models.