we found that CREB and a dominant-negative CREB have opposite effects on gene expression, as do prolonged expression of ΔFosB and the activator protein-1 (AP-1) antagonist ΔcJun. However ...

Phosphorylation of CREB family members promotes target gene expression through the recruitment of the coactivator CREB-binding protein (CBP) and its paralogue p300. Phosphorylation of CREB at ...

These processes are regulated by the transcription factor CREB, which regulates gene expression in neuronal activity-dependent processes. Neuronal activity enhances CREB-mediated transcription but ...

Activity-dependent repetitive CREB binding to DNA occurred at histone acetylation sites (lower left), where active RNAPII accumulation induces gene expression (lower right). Dashed lines indicate ...

In a new study appearing on October 3 in The Journal of Clinical Investigation, Subhash Pandey and colleagues from The University of Illinois show that decreased function of the CREB gene ...

The database focuses on CREB target genes with information on binding sites, promoter occupancy, and gene activation by cAMP. While the information is extensive and useful, interpretation of the ...

Kukushkin and colleagues set out to determine whether CREB in nonneuronal cells responds to incoming signals the same way. The researchers inserted an artificial gene into human embryonic kidney ...

The researchers compared gene expression after water maze training and found that BDNF and other memory-related genes controlled by CREB were less active in the mutant mice compared to wild type, ...

"These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes ... element binding protein (CREB), a transcription factor known ...

In mice learning to dislike saltwater, new memories favor neurons with high levels of the cyclic-AMP-response-element-binding protein (CREB), according to a study published today (November 13) in ...

These processes are regulated by the transcription factor CREB, which regulates gene expression in neuronal activity-dependent processes. Neuronal activity enhances CREB-mediated transcription but ...