TOPLINE: Chronic lymphocytic leukemia (CLL) cell–derived exosomes demonstrated the ability to alter healthy donor cell function and suppress normal blood cell formation. These particles affected ...

Abbvie (($CC:ABBV.CUR)) announced an update on their ongoing clinical study. AbbVie is conducting a clinical study titled ‘A ...

Chronic lymphocytic leukemia (CLL) is the most common leukemia diagnosed in adults. What sets CLL apart from other leukemia types include where it starts and how fast it usually grows.

Chronic lymphocytic leukemia (CLL) cells proliferate in secondary lymphoid organs (lymph nodes and spleen), where B-cell receptor signaling promotes the expansion of the monoclonal B lymphocytes ...

Cells were sorted by expression into CLL clone cells (CD5/CD19-positive) or subpopulations that were CD5/CXCR4-positive and CD5/IgM-positive. About 10% to 15% of the CLL cell population was found ...

This seems likely to be promoted by CLL cell secretion of T-cell attracting chemokines CCL3 (298pg/m1±197.5) and CCL4 (56pg/m1±115.6) in our model. Interestingly, CD38+ CLL samples showed elevated ...

Chronic lymphocytic leukemia comes on slowly, and it can take decades before someone with CLL starts to show any symptoms. The symptoms are caused by the abnormal cells pushing out the healthy ...

CLL cells secrete cytokines and chemokines in the TME that support the formation of cancer cells. Those include IL-9, the release of which has been linked with aggressive cases of CLL.

These investigators report on a model for the clinical course of CLL from an indolent genomic state to regression or progression, based on the interplay between genomic and microenvironmental changes.

Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental factors for proliferation and survival. In particular, the B-cell receptor (BCR) and nuclear factor- κB (NF-κB) pathways are ...

Chronic lymphocytic leukemia (CLL) cells require complex microenvironmental and immunologic interactions to survive and proliferate. Such interactions might be best recreated in animal models ...