The internationalization of the CEACAM5-dependent ADC occurs after IBI3020 selectively binds to CEACAM5-expressing tumor cells, followed by lysosomal degradation. This process releases two types ...

The drug, which targets carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) on tumour cells, was unable to improve progression-free survival in the CARMEN-LC03 trial in previously ...

PD-L1 ISAC directly activates and reprograms PD-L1-expressing myeloid cells in the TME to drive complete responses and immunological memory ...