The disorder involves losing the function of a gene producing the CDKL5 enzyme, which phosphorylates proteins, meaning it adds an extra phosphate molecule to alter their function.

UCB, a global biopharmaceutical company, today announced that the Phase 3 study investigating the safety and efficacy of adjunctive fenfluramine in CDKL5 deficiency disorder (CDD) met its primary ...

The global, double-blind, placebo-controlled, Phase 3 trial enrolled 101 patients. Children and young adults ages 2 to 21 with a confirmed, disease-related CDKL5 gene variant were eligible to enroll.

The disease stems from a mutation of the CDKL5 gene, which encodes proteins that are key to normal development and function of the brain. This gene is located on the X chromosome; CDKL5 deficiency ...

--Ovid Therapeutics Inc., a biopharmaceutical company committed to developing medicines that transform the lives of people with rare neurological diseases, today announced initial data from its ...

Terzic, B., et al. (2021) Temporal manipulation of Cdkl5 reveals essential postdevelopmental functions and reversible CDKL5 deficiency disorder–related deficits.

Topline data were announced from a phase 3 trial that evaluated adjunctive fenfluramine in patients with cyclin dependent kinase-like 5 (CDKL5) deficiency disorder (CDD), a rare developmental ...

The disorder involves losing the function of a gene producing the CDKL5 enzyme, which phosphorylates proteins, meaning it adds an extra phosphate molecule to alter their function.

CDKL5 Deficiency Disorder (CDD) is a devastating neurodevelopmental disorder caused by mutations in the CDKL5 gene. The Loulou Foundation, a private non-profit foundation dedicated to the development ...

CDKL5 deficiency disorder affects around one in 40,000 children -- or people. And it is one of the top 10 monogenic epilepsies, as we know them today.

BALLSTON SPA, N.Y. (NEWS10) — A family in Ballston Spa is asking for the community’s help this June for CDKL5 Deficiency Disorder Awareness Month — a rare genetic disorder that only about ...

CDKL5 Deficiency Disorder Voice of the Patient Report Submitted to FDA June 17, 2020 11:12 AM Eastern Daylight Time ...