A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University revealed that elevated activity of cdc42 is a critical initiation event leading to proteinuria, and ...

Rho GTPases Cdc42 and RacA share significant sequence homology and are conserved among eukaryotic species. These proteins act as molecular switches in various signal transduction pathways by ...

Rho GTPases control many cytoskeleton-dependent processes, but how they regulate spatially distinct features of cytoskeletal function within a single cell is poorly understood. Here, we studied active ...

This study links RhoA/ROCK pathway activity to nanoscale sensing, showing how cytoskeletal tension modulates cell ...