Preclinical mouse studies have shown that in cases of metastatic melanoma, certain immune cells called CD8+ T cells have high levels of a protein called PD-1, which inhibits or prevents the CD8+ T ...

Orange indicates Merkel carcinoma cells expressing neuron-specific enolase, yellow CD8+ T cells, red CD68+ macrophages, white PD-1, green the PD-1 ligand PD-L1, and blue nuclear DNA stained with 4 ...

Findings indicate that frequent COVID-19 booster shots do not weaken T-cell responses, alleviating concerns for vulnerable ...

Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years ...

CD8+ tumor-infiltrating lymphocytes and mucin expression in rectal cancer." DNA damage and resulting neoantigen formation is considered a mechanism for synergy between radiotherapy and PD-1/PD-L1 ...

This panel includes markers for T cells (CD8 and FoxP3), macrophages (CD68), checkpoint inhibitors (PD-1 and PD-L1), and PanCK as a tumor marker. Stained TMAs were scanned at 20× magnification on ...

Findings presented at the AD/PD meeting, held earlier this month in Vienna ... The scientists also intravenously injected the mice with OT-1 T cells—an ovalbumin-specific CD8+ T cell clone. A week ...

FMT had been performed using colonoscopy, followed by continuation or reintroduction of anti-PD-(L)1 until acceptable toxicity ... activated human CD4- and CD8-positive T cells and suppressed ...