T cells may be broadly classified as either helper T cells (Th cells, CD4+) or cytotoxic T cells (Tc cells ... cytokines the cells secrete in response to antigenic stimulation.1 Th1 cells primarily ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Researchers cultured murine helper T (CD4-expressing) cells at 37°C or 39 ... Short Palindromic Repeats (CRISPR) screening among Th1 cells to determine the molecular basis of cell death.

Improper self-antigen recognition by DCs and T-cell initiates, through release of specific cytokines (as described above), destructive Th1 or Th2 responses. RA, for example, is characterized by an ...

In conclusion, Tim-3 was characterized as a novel immune checkpoint molecule with pathophysiological significance in respiratory oncology. Its stage-dependent expression dynamics and multimodal ...