Delve into the landscape of biotech companies developing treatments for HIV and find out if we are getting closer to a cure.

1) Protein and cells, from left to right: engineered protein with yellow-and-black CD3-binding end and thick black HIV-binding end; latently HIV-infected helper T cell (blue); inactivated killer T ...

The CD3 downregulation function was lost in chimpanzee immunodeficiency virus (SIV CPZ) prior to the infection of humans. Since HIV-1 Nef does not downregulate CD3 humans progress to AIDS as ...

It contains one Ig-like (immunoglobulin-like) domain and one ITAM domain. CD3E, along with CD3-gamma, CD3-delta, CD3-zeta, and T-cell receptor (TCR) alpha/beta or gamma/delta heterodimers ...

Notably, IFT20 clusters with TCRs at the immune synapse and associates with the ζ- and ɛ-chains of CD3 in response to TCR engagement. TCR–CD3 complex assembly is initiated in the endoplasmic ...

CD20 × CD3 bispecific antibodies bind to both CD20 on malignant B cells and CD3 on T cells, bringing them into close proximity, which triggers T cell-mediated killing of the targeted B cells.