CD3 expression was mostly diffuse (12/17) and moderate to strong (11/16) with a cytoplasmic staining pattern (14/16). Other T-cell markers were nearly absent, including CD2 (0/10), CD4 (1/13), CD5 ...

newer developments of bispecific antibodies that target CD38/CD3 are in the pipeline – taking full advantage of recent breakthrough studies. 2 Why choose CD38 target to treat MM? The expression ...

CD3 (including its subunits CD3ε ... significantly impacting gene expression and apoptosis processes. CD3γ is essential for establishing and maintaining cell polarity, assembling and ...

Paraffin-embedded specimens were examined using light microscopy and immunohistochemistry (via the PAP horseradish peroxidase technique) to detect the expression of CD3, CD20, CD34 and CD68 ...

and its expression correlates with disease progression. T cell engager antibodies that are designed to target tumor antigens and T cell CD3 are one of the most active fields in the development of ...

and CD74 CD3 expression was a good predictor for tumor progression at five months in recurrent glioblastoma subjects treated with MN-166 (ibudilast) and TMZ as subjects with progression had higher ...

CD3+ tumor-infiltrating T cells were detected ... death in multivariate analysis and was associated with increased expression of interferon-γ, interleukin-2, and lymphocyte-attracting chemokines ...

(A, C) patient 10; (B, D) patient 18. (A and B) Immunohistochemistry for CD3 expression in tumor biopsy. (C and D) Transgene detection in tumor biopsy and corresponding peripheral-blood sample.

“In our patients, PD-L1 expression on pretreatment sTILs inversely correlated with CD3 expression on sTILs in residual disease after SC trastuzumab, thus suggesting that SC administration of ...

on tumor cells and CD3 expression on T cells and up to three additional pre-clinical TCE antibodies currently at an earlier discovery stage. WuXi Biologics will receive a $40 million upfront ...

Anti–T-cell (CD3 and T-cell receptor ... 64 Tissue-specific cells contribute to disease expression, and their importance should not be underestimated. In the kidney, mesangial cells ...

Although this study identified time to relapse and CD3 expression as potential prognostic factors, the optimal use of allo-HSCT versus auto-HSCT remained uncertain with the exception of patients who ...