the authors used a CD3-specific cross-linking antibody to cluster the CD3 molecules. Regardless of CD3 cluster formation, phosphorylation of ERK was lower in CD3ɛ mutant mice than wild-type mice ...

The trial aims to evaluate the antibody’s efficacy in treating non-active secondary progressive multiple sclerosis.

Notably, IFT20 clusters with TCRs at the immune synapse and associates with the ζ- and ɛ-chains of CD3 in response to TCR engagement. TCR–CD3 complex assembly is initiated in the endoplasmic ...

CD20 × CD3 bispecific antibodies bind to both CD20 on malignant B cells and CD3 on T cells, bringing them into close proximity, which triggers T cell-mediated killing of the targeted B cells.

These optimal 3S TCRs can subsequently be merged with a Cluster of Differentiation 3 (CD3) T cell engaging antibody. The TCR-TCEs specifically redirect the patient’s own T cells towards the cancer ...