GMP ActiveMax ® Human T Cell Activation/Expansion CD3/CD28 Beads are supplied at a concentration of 5 × 10 7 beads/mL in PBS (pH 7.4), containing 0.1% recombinant human serum albumin ...

Anti-CD3/CD28 antibody-coupled magnetic beads can effectively expand T cells and have a higher expansion ability than that of other competitors.

T-helper (Th) lineages have been generated in vitro by activating CD4 cells with anti-CD3/CD28 antibodies during polarization. Physiologically, however, the generation of Th lineages is by ...

CD28 ligation cosuppresses superantigen and CD3-independent T-cell activation. The high frequency of T cells responsive to CD3 ligation invited speculation as to whether a milder form of T-cell ...

To aid in the production of desired phenotypes, CD3/CD28 active-release beads have been developed to add extra flexibility and further shorten the manufacturing process. This application note ...

PHILADELPHIA and OXFORD, United Kingdom, June 21, 2016 (GLOBE NEWSWIRE) -- Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in T-cell therapy to treat cancer, today announced that it has ...

The CD28 signal is diminished in cancer because tumor cells do not typically express CD28 ligands (i.e., CD80 and CD86), which leads to potentially compromised activity of CD3 T cell engagers or ...

Multiple studies have now demonstrated that 4-1BBL can independently provide co-stimulatory signals to induce T cell proliferation, separate from CD28 molecule signaling. Our other products for T cell ...

Clinical Progress Updates in Early-Stage Oncology Programs: XmAb819 (ENPP3 x CD3) and XmAb808 (B7-H3 x CD28) XmAb819: ENPP3 x CD3 bispecific T-cell engager in Phase 1 dose escalation for patients ...

CD3/CD27 or CD3/CD28 costimulated CAR-T cells were infused into mouse models of B cell lymphoma, lung cancer and breast cancer. In all cases, CD3/CD27 costimulated CAR-T cells displayed enhanced and ...

REGN5678 is designed to bind to CD28 on cytotoxic T-lymphocytes ... Regeneron identified the targeting of CD28 on previously activated T cells as a way to reduce toxicity compared to CD3 bispecifics.

Lamkap Bio Alpha AG's κλ bispecific antibodies include a κ light chain recognizing one target and a λ light chain recognizing a second target. The company has presented data showing the benefit of ...