Here we demonstrate that integrin CD11b is a critical negative regulator of mycobacteria cord factor-induced macrophage-inducible C-type lectin (Mincle) signaling. CD11b deficiency resulted in ...

CD11b deficiency resulted in significantly upregulated ... were obtained from Cell Signaling Technology Inc. (Beverly, MA). Anti-phospho-Lyn (Tyr507, 1:2000) and anti-phosphotyrosine (4G10 ...