The c-kit-encoded transmembrane tyrosine kinase receptor for stem cell factor (Kit/SCF-R) is required for normal haematopoiesis, melanogenesis and gametogenesis1,2,3.

The stem-cell-factor receptor known as <i>c-kit</i> plays an important signaling role in mediating bone-marrow-derived natural-killer- and angiogenic-cell mobilization, ultimately helping with ...

Oncogenic c-Kit mutations have been shown to display ligand-independent receptor activation and cell proliferation. A substitution of aspartate to valine at amino acid 816 (D816V) is one of the ...

Stem cell factor and its receptor, the KIT proto-oncogene receptor tyrosine kinase (hereafter referred to as KIT), are essential for normal mast-cell development and survival in the tissues. 11 ...

Telatinib (BAY 57-9352) is an orally available tyrosine kinase inhibitor of vascular endothelial growth factor receptor (VEGFR) -2, VEGFR-3, platelet-derived growth factor receptor-β, and c-Kit. This ...

The activated form of the c-Kit receptor is often expressed in GISTs, and is thus a good candidate for treatment with TKIs that inhibit c-Kit activity, such as the FDA-approved agent imatinib ...

Briquilimab is a targeted aglycosylated monoclonal antibody that blocks stem cell factor from binding to the cell-surface receptor c-Kit, also known as CD117, thereby inhibiting signaling through ...

This study aimed to assess the antitumor activity of imatinib in adenoid cystic carcinoma (ACC) of the salivary gland expressing c-kit. A high level of c-kit expression has been identified in more ...

SCF binds a tyrosine kinase receptor, c-kit, which results in the dimerization of the c-kit receptor and the subsequent activation of the tyrosine kinase domain.

Briquilimab is a targeted aglycosylated monoclonal antibody that blocks stem cell factor from binding to the cell-surface receptor c-Kit, also known as CD117, thereby inhibiting signaling through ...

Briquilimab (JSP191) is an unconjugated, aglycosylated, anti-c-Kit antibody that functionally blocks the interaction of the c-Kit receptor from its ligand, stem cell factor (SCF).