The Myc-gene plays an important role in cell regulation; in about 50% of all tumors this gene is mutated. Scientists have shown that the gene BASP1 specifically inhibits the effect of this ...

The Myc-gene plays an important role in cell regulation; in about 50 percent of all tumors this gene is mutated. Scientists led by Professor Klaus Bister of the University of Innsbruck, Austria ...

Fig 2: A. BASP1 localization is cell context-dependent. BASP1 is nuclear in a kidney cancer cell line (top), but not Cos 7 kidney cells (bottom). B. Sumoylated BASP1 is directed to PML bodies within ...

BASP1-VHH fusions improved exosome AAV capsid loading by 2-3 log orders, while retaining transduction activity. The highest performing engineered engEx-AAV constructs showed significant ...

Figure 1: BASP1 (acting as part of a complex) interacts directly with WT1 at a gene promoter and converts WT1 from a transcriptional activator to a repressor. The phospholipid PIP2 is required for ...

The paper, entitled “A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties,” by Dooley et al, will appear in an upcoming print issue of ...

Now, Johns Hopkins Medicine scientists say they have found a molecular connector, known as the BASP1 receptor, that binds cocaine, even when the drug is present in very low doses. Advanced Search Home ...

Scientists have long known that cocaine works by latching on to molecular connectors on the surface of brain cells, allowing dopamine, a chemical that promotes feelings of pleasure and reward, to ...

Now scientists say they have found a molecular connector, known as the BASP1 receptor, that binds cocaine, even when the drug is present in very low doses. Skip to main content.

Now, Johns Hopkins Medicine scientists say they have found a molecular connector, known as the BASP1 receptor, that binds cocaine, even when the drug is present in very low doses.