In contrast, a different RCMT, called NSUN1, interacts with BRD4, a histone modifier, to recruit RNA-pol-II to form a different active chromatin structure at nascent 5-AZA-resistant leukemia cells.

Cells use RNA as a versatile tool to regulate the activity ... Normally, Dicer works with a gene-activating protein called BRD4. The research team found that when Dicer was broken and BRD4 was ...

Bromodomain protein 4 (BRD4), a transcriptional regulator, plays a crucial role in autoimmunity, cancer, and inflammatory diseases. 1,2 Researchers found that BRD4 is a protein attached to ...

The following antibodies were used in ChIP assays: anti-BRD4 (E2A7X, Cell Signaling), anti-H3K27ac (ab4729, Abcam), anti-H3K79me2 (ab3594, Abcam) and anti-RNA POL II (CTD4H8, Millipore).

In a recent study published in CANCER RESEARCH, a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule ... expression of two proteins called ...

A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target ...

Researchers identified a small RNA molecule called miR-766-5p that reduces expression of MYC, a critical cancer-promoting gene. This microRNA reduces levels of proteins CBP and BRD4, which are ...

BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.

BUFFALO, NY- September 13, 2023 – A new research paper was published in Genes & Cancer on September 12, 2023, entitled, “Increased expression of BRD4 isoforms long (BRD4-L) and short (BRD4-S ...

In a recent study published in CANCER RESEARCH, a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule ... expression of two proteins called ...

A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target ...