A new study shows exactly how the gene BRCA2, linked to susceptibility to breast and ovarian cancer, functions to repair damaged DNA. By studying BRCA2 at the level of single molecules, researchers at ...

The function of BRCA2 is to load up with RAD51 (each BRCA2 can carry up to six RAD51s), push another protein called RPA out of the way and put the proteins onto the DNA.

By visualizing BRCA2 function at a single molecule level, Kowalczykowski’s team discovered that it acts as a molecular chaperone, delivering another protein, RAD51, to single-stranded DNA.

Inherited mutations in the gene BRCA2 significantly increase the risk of carriers to breast and ovarian cancers. BRCA2, a crucial player in the body's DNA repair system, aids in repairing damaged DNA.

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

People who have a BRCA2 loss-of-function pathogenic mutation have a 69% lifetime risk for developing breast cancer and a 15% risk for ovarian cancer, according to study background.

However, BRCA2 function in the suppression of gaps is important for protecting cells from a potentially new class of drugs resulting in the incorporation of aberrant nucleotides in DNA. These findings ...

Having a structure of this complex in hand, researchers may now find new approaches to regain BRCA2 function in MEILB2-positive cancers, Nandakumar suggests.

The MEILB2 protein sandwich carries the BRCA2 protein precisely to the DNA break points. To determine the structure of this BRCA2 complex, the researchers used X-ray crystallography.

Varanasi: Genes associated with breast cancer also play an important role in the health of heart, said Dr Krishna Singh, ...