In humans, mutations in the BRCA1 gene increase the risk of breast, ovarian, and other cancers by impairing an important pathway for the repair of damaged DNA. Lead investigator Andre Nussenzweig ...

EastEnders star, Kara Tointon, has bravely revealed she's had a double mastectomy after finding out she carries the deadly ...

However little was known about the importance of this activity in DNA repair. The new research has found that this attachment of ubiquitin by BRCA1, its 'ubiquitin ligase activity', is needed for ...

Defective DNA repair may contribute to neurological disorders, including Alzheimer’s disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD ...

BRCA1 functions as a 'caretaker' of genome stability and exerts multiple effects on key cellular processes involved in DNA damage repair, transcriptional regulation, ubiquitination and cell-cycle ...

Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other copy is inactivated by an inherited mutation. This means that a total ...

The former EastEnders star, 41, found out she carries the deadly BRCA1 gene - and made the brave decision to undergo a double ...

The full name of the BRCA1 gene is “breast cancer 1, early onset,” and it codes for a tumor suppressor protein. Tumor suppressor proteins help repair DNA that has become damaged in order to ...

EastEnders and Strictly Come Dancing star Kara Tointon has revealed that she has undergone a double mastectomy after finding ...

The BRCA1 gene was mapped in 1990 and cloned in 1994 and the BRCA2 gene was isolated one year later. These proteins mainly maintain genomic integrity through DNA repair and the regulation of ...

In humans, mutations in the BRCA1 gene increase the risk of breast, ovarian, and other cancers by impairing an important pathway for the repair of damaged DNA. Lead investigator Andre Nussenzweig, ...