after a five-member panel at the school alleged that he had tampered with data related to the antibody assay he developed to test how BRCA1 encodes a protein to repair DNA damage. His case is now ...

Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other copy is inactivated by an inherited mutation. This means that a total ...

The limited involvement of BRCA1 suggests that tumors harboring BRCA1 variants may not rely on homologous repair deficiency, potentially limiting their responsiveness to PARP [inhibitor]-based ...

Researchers from the University of Iowa have unveiled the structure of a protein that plays a key role in protecting DNA ...

The double ring, spool-like structure of RAD52 protects replicating DNA in dividing cells. A study led by the University of ...

Scientists at the University of Iowa have made an exciting discovery that could lead to new cancer-fighting drugs. They found ...

1,5 Most tumor cells exploit weaknesses in the DNA repair system to induce genomic instability and accumulate genetic changes that promote survival or metastasis. For example, BRCA1 and BRCA2 ...

Triple-negative breast cancers are often characterized by defects in DNA repair mechanisms involving ... cancer type 1 susceptibility protein (BRCA1). Indeed, mutations in BRCA1 are known to ...

Patients with genetic alterations in the DNA repair genes BRCA1, BRCA2 or ATM who received olaparib had a median overall survival of 19.1 months, compared with 14.7 months for those on targeted ...