Transfection into HCT116 cells was performed using lipofectin ... along with 5 µg of pcDNA–BRCA1, 2.5 µg of pRcCMV–CtBP, 2.5 µg of pCNF–CtIP(WT), pCNF–CtIP(S664/745A), pCNF ...

The BRCA1 gene is located on the long arm of chromosome 17, at position 17q21. The gene spans around 100 kilobases and codes for a protein containing 1863 amino acids. Mutations or alterations ...

The BRCA1 gene is a sequence located on the long arm of chromosome 17, at position 17q21. The gene spans around 100 kilobases and codes for a tumor suppressor protein containing 1863 amino acids.

Mutations in the tumor-suppressing gene BRCA1 can increase the risk of cancer Harmful BRCA mutations can increase a woman's risk for breast cancer five times BRCA1 and BRCA 2 are types of tumor ...

Doctors have long recognized that women with mutations in two particular genes – BRCA1 and BRCA2 – have a higher risk of breast and ovarian cancer. Now they are starting to figure out which ...

BRCA1 is one of the best-studied cancer genes in the world. Still, on occasion, doctors will test a patient and find a BRCA1 mutation no one has ever seen before. This creates a dilemma.

Researchers report a new, previously unrecognized function of the BRCA1 gene that explains why BRCA1 gene mutation carriers are at increased risk of breast and ovarian cancer. The human body holds ...