Additional inherited mutations may also occur in other members of the BRCA1–BRCA2–HR pathway, such as partner and localizer of BRCA2 (PALB2) and BRCA1-interacting protein C-terminal helicase 1 ...

Inhibiting the action of a particular enzyme dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic ... DNA via a disruptive DNA repair pathway termed alt-NHEJ," says Dr ...

Scientists have developed a new clinical pathway for testing for the cancer-causing faults in the BRCA gene that could ensure patients get the right treatment and boost the number of people who ...

The researchers first looked at yeast to demonstrate that a molecular pathway that is particularly susceptible to BRCA1 influence is also crucial to normal cell function. “The BRCA1 pathway we ...

In humans, mutations in the BRCA1 gene increase the risk of breast, ovarian, and other cancers by impairing an important pathway for the repair of damaged DNA. Lead investigator Andre Nussenzweig ...

Theoretically, an inhibitor of the FA–BRCA pathway may resensitize the relapsed tumor to cisplatin. The finding that the FA–BRCA pathway is intimately involved in the response to DNA damage ...

New research suggests that BRCA1 and BRCA2 gene mutations lead to hereditary ovarian cancers through different pathways, but that these pathways may be similar to ones at work in sporadic ovarian ...

From antibody-drug conjugates to PARP inhibitors, innovative treatments are offering new hope for patients with ...

BRCATrue has a sensitivity of >99.99% and the broadest coverage across BRCA1/2 in the industry. (Photo: Business Wire) To enhance the accessibility of this important genetic test, Pathway Genomics ...

In humans, mutations in the BRCA1 gene increase the risk of breast, ovarian, and other cancers by impairing an important pathway for the repair of damaged DNA. Lead investigator Andre Nussenzweig, ...