Remarkably, Jensen said, the BRCA2 gene effectively shields these complexes, maintaining the integrity and function of DNA repair pathways. "Cancer cells can somehow tolerate the loss of the BRCA2 ...

A new study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP ...

A study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.

Bloomston emphasized the importance of awareness regarding conditions linked to pancreatic cancer, such as the BRCA mutation, ...

Remarkably, Jensen said, the BRCA2 gene effectively shields these complexes, maintaining the integrity and function of DNA repair pathways. Cancer cells can somehow tolerate the loss of the BRCA2 ...

In BC, dysregulation of the DDR pathway, often due to mutations in genes like BRCA1 and BRCA2, impairs DNA repair, leading to genomic instability and an increased risk of cancer. "Innovations in ...

Benefit in these BRCA wild-type patients may reflect the unique, dual therapeutic action of stenoparib in inhibiting not only PARP but also the Wnt pathway—a pathway activated in ovarian ...