The B cell receptor (BCR) signaling pathway regulates B cell activation, and Fc receptor-like proteins may contribute to this pathway’s activation or inhibition. Previous studies have demonstrated ...

The team investigated when BCR::ABL1 first arises in a blood cell and how quickly these cells with this genetic change then multiply and expand to lead to a diagnosis of a type of leukemia.

A pioneering study uncovers crucial immune dynamics in hepatitis B, offering new insights into how immune responses evolve ...

BCR-ABL point mutants resistant to the second generation inhibitors nilotinib and dasatinib have been identified through cell-based resistance screens. Strategies to circumvent the emergence of ...

Dasatinib eradicated Bcr/Abl ALL cells, caused significant apoptosis ... Interestingly, dasatinib treatment increased cell-surface expression of CXCR4, which is important for survival of B-lineage ...