“BAP1 is a tumor suppressor gene (that) is … known to be associated with aggressive RCC tumors and regulates key cellular pathways, including the (DNA repair) pathway,” Ged said in a presentation of ...

Inherited mutations in DNA-repair genes such as BRCA2 are associated ... Of the 20 genes analyzed, 4 (BAP1, BARD1, MLH1, and XRCC2) had no presumed pathogenic germline mutations.

A new study reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM).

In a recent study published in Nature Genetics, researchers performed saturation genome editing (SGE) of the BRCA1-associated protein-1 gene (BAP1), whose ... a HAP1 DNA ligase 4 (LIG4) knockout ...

This raised two possibilities for the researchers: these four families were related although they did not know it, or researchers had found a hot spot for BAP1 mutations. In the findings published ...

New study from researchers in Finland and the United Kingdom reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ...

"One of the most common genetic alterations that initiates the development of uveal melanoma occurs in a tumor suppressor gene called BAP1. This gene is found absent or mutated in almost 50% of ...

"One of the most common genetic alterations that initiates the development of uveal melanoma occurs in a tumor suppressor gene called BAP1. This gene is found absent or mutated in almost 50% of ...