The results of immunohistochemical staining for BAP1 in these tissue biopsy samples has been previously reported. 21 We also searched for all cases of thoracic mesothelioma receiving a definitive ...

Pleural biopsy is often the preferred diagnostic method ... Panel B shows loss of BAP1 nuclear staining in tumor cells, with BAP1 staining retained in alveolar and inflammatory cells (pink).

A new study reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM).

with BAP1 TPDS included in the study, 41 (87.2%) presented nail abnormalities of which 39 (83%) were consistent with onychopapilloma. Five patients underwent nail unit biopsy which confirmed their ...

HOUSTON - Researchers at The University of Texas MD Anderson Cancer Center have shown how BRCA-associated protein 1 (BAP1) serves as a tumor suppressor gene in kidney, eye, bile duct, mesothelioma ...

Around 60%-70% of malignant mesotheliomas present mutated or deleted BAP1 tumor suppressor. BAP1 is a catalytic subunit of the polycomb repressive deubiquitinating (PR-DUB) complex, and its loss ...

Called BAP1 tumor predisposition syndrome, it affects a gene that prevents the body's cells from growing at a rapid rate, and developing into tumorous masses. The gene also plays a crucial role in ...

Human PR-DUB complex is composed of ubiquitin C-terminal hydrolase BAP1 (BRCA1 associated protein 1) and one of the three Additional Sex comb Like (ASXL) proteins ASXL1/2/3. BAP1 is also a tumor ...

Using this method, they have found that mutations in BAP1, a gene commonly mutated in liver cancer, changes the behavior of the cells, which may make them more likely to be invasive. Researchers ...

"One of the most common genetic alterations that initiates the development of uveal melanoma occurs in a tumor suppressor gene called BAP1. This gene is found absent or mutated in almost 50% of ...