This protocol is for the ultrasound (US)-assisted 1,3-dipolar cycloaddition reaction of azides and alkynes using metallic copper (Cu) as the catalyst. The azido group is a willing participant in ...

The strategy is inspired by the copper (I)-catalyzed azide-alkyne cycloaddition, well-known as the click reaction, in which azide and alkyne groups react with the aid of a copper catalyst to form ...

Nickel-Catalyzed Azide–Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water. Journal of the American Chemical Society, 2017; 139 (35): 12121 DOI: 10.1021/jacs.7b06338 ...

The most popular of the click reactions, the copper (I)-catalyzed azide-alkyne cycloaddition, or CuAAC, is commonly used by chemical biologists, materials scientists, and polymer chemists.

Copper is toxic to living cells, but she figured out a way to produce a copper-free click reaction, called the strain-promoted azide-alkyne cycloaddition, and showed it could be used to treat tumours.

Bioorthogonal reactions are a series of chemical reactions that occur in biological environments with high yields, selectivity, efficiency, and no side reactions. These reactions include ...

Azide-alkyne cycloaddition is much faster, but the conventional copper catalysts required are toxic to living systems. Bertozzi's team has designed a reagent that eliminates those copper catalysts.

In 2002, Meldal and Sharpless independently arrived at what is considered the ‘ideal’ click chemistry reaction: the copper-catalyzed azide–alkyne cycloaddition. This reaction easily links molecules ...

Versatility: Copper-free click chemistry methods, such as strain-promoted azide-alkyne cycloaddition (SPAAC) and inverse-electron-demand Diels-Alder (IEDDA) reactions, are versatile and can be adapted ...