Please use one of the following formats to cite this article in your essay, paper or report: APA. Kumar Malesu, Vijay. (2025, January 07). Researchers uncover diverse asthma endotypes in youths ...

Most youths with asthma had T17HIGH and T2LOW/T17LOW endotypes of the disease based on transcriptomic profiles of nasal epithelium, according to a study published in JAMA. Generally, T2HIGH has ...

The authors further stated, “A promising approach to characterizing transcriptomic profiles of asthma endotypes in youth is nasal sampling, given its safety, feasibility, and evidence of high ...

SAN DIEGO — Nasal sampling revealed three asthma endotypes among minoritized youth that could be potential targets for treatment, according to an abstract presented at the American Thoracic ...

More information: Molin Yue et al. Transcriptomic profiles in nasal epithelium and asthma endotypes in youth, JAMA (2025). DOI: 10.1001/jama.2024.22684. Provided by University of Pittsburgh.

Asthma comes in different subtypes, but diagnosing those subtypes — also known as endotypes — has historically been difficult. Newly published research in JAMA presents an alternative: a nasal ...

“This research was important because asthma is a heterogeneous disease with various endotypes (T2-high, T17-high, T2-low/T17-low), but most prior studies on asthma focused on T2-high endotypes ...

But not much is known about whether varying asthma endotypes play a role in the disparity. Celedón said the swabs could also be used to learn more about how age and sex play a role in asthma.

"Because asthma is a highly variable disease with different endotypes, which are driven by different immune cells and respond differently to treatments, the first step toward better therapies is ...

The test diagnoses a child's asthma subtype, also called an endotype. "Because asthma is a highly variable disease with different endotypes, which are driven by different immune cells and respond ...

Asthma comes in different subtypes, but diagnosing those subtypes — also known as endotypes — has historically been difficult. Newly published research in JAMA presents an alternative: a nasal ...

However, no available asthma biologics directly target T17-high and low-low endotypes. "We have better treatments for T2-high disease, in part, because better markers have propelled research on ...