Top row: In a mouse model of Alzheimer’s disease ... including the most well-known, APOE. Replenishing lithium by giving the mice lithium orotate in their water reversed the disease-related damage and ...

A humanized mouse model has been generated in which the APOE-TOMM40 region in the mouse was replaced with its human counterpart, including upstream and downstream regulatory sequencees (Gottschalk et ...

In the new study, Huang's team developed a "chimeric" mouse model that not only carries human APOE genes, but also contains human neurons that are transplanted into the brain. Importantly, the ...

Additionally, they showed in mouse models that the death of retinal ganglion cells can be prevented by using medications to inhibit a molecule called Galectin-3, which is regulated by the APOE gene.

And targeting the APOE protein with an antibody clears a significant amount of plaques in mouse models of Alzheimer’s, the scientists found.

Alas, if toxic forms of tau are around, ApoE makes things worse. Using human ApoE knock-in mice crossed to the P301S tau model of tauopathy, Holtzman and colleagues previously reported that expression ...