Scientists used advanced cryo-EM imaging to reveal how glutamate activates brain receptors, paving the way for new ...

Its landing place on neurons is a channel called an AMPA receptor, which interacts with glutamate, and then acts like a pore ...

Researchers used advanced cryo-electron microscopy to capture atomic-level images of how glutamate, a key neurotransmitter, ...

A new study by McGill University researchers yields insights into how the disruption of calcium transport in the brain is ...

Silent synapses are dormant neural connections that hold untapped brain potential. Discover how ketamine, exercise, and other ...

A new study by McGill University researchers yields insights into how the disruption of calcium transport in the brain is linked to autism and intellectual disability.

More information: Federico Miguez-Cabello et al, GluA2-containing AMPA receptors form a continuum of Ca 2+-permeable channels, Nature (2025). DOI: 10.1038/s41586-025-08736-2 ...

The AMPA group of brain receptors have mostly been assumed to be calcium impermeable and so were not thought to contribute to the calcium-dependent mechanisms underlying learning and memory.