Rein Therapeutics ("Rein") (NASDAQ: RNTX), a biopharmaceutical company advancing a novel pipeline of first-in-class medicines ...

Impact Journals LLC image: Figure 7. Summary of in vitro and ex vivo systems to mimic alveolar epithelial and fibroblast damage and dysfunction in the IPF lung. view more Credit: 2024 Spina et al.

Rein Therapeutics ("Rein") (NASDAQ: RNTX), a biopharmaceutical company advancing a novel pipeline of first-in-class medicines ...

The pathophysiology involves repeated alveolar epithelial injury followed by abnormal wound healing, which promotes fibroblast proliferation and excessive extracellular matrix deposition.

In humans with idiopathic pulmonary fibrosis (IPF), AEC2 never leave the transitional state, and change into AEC1, leading to the development of scar tissue known as fibrosis.

Our second presentation used alveolar organoid systems derived from donor or IPF lung epithelial cells to demonstrate LTI-03's potential to promote and sustain type 2 alveolar epithelial cell, or ...

They found that the resemblances included that COVID-19 recapitulates the gene expression patterns (ViP and IPF signatures), cytokine storm (IL15-centric), and the AT2 cytopathic changes, eg ...

Study: Persistent alveolar type 2 dysfunction and lung structural derangement in post-acute COVID-19. Image Credit: Darryl Fonseka/Shutterstock *Important notice: medRxiv publishes preliminary ...

BioWorld Content on 'progressive IPF'A Chinese study has established a previously unknown direct mechanistic link between elevated mechanical tension caused by impaired alveolar regeneration and ...