Further experiments revealed that TP63, an oncogene, acts as a "master switch" for ALDH3A1. It directly activates the ALDH3A1 gene, triggering the protective mechanism. When the researchers turned ...

ALDH3A1 is overexpressed by TP63 transcriptional regulation in squamous cell carcinoma and plays an anti-ferroptosis role by metabolising toxic aldehydes. Advanced Search Home ...