To make the aldehyde (5), dinitrile (6) was first converted into diester. Then, the hydroxy groups in diester were protected with a tert-butyldiphenylsilyl (TBDPS) group to form protected ether.

Initial attempts on intramolecular α-cyclopropanation. Enantioselective α-halogenation of aldehydes have been reported by several research groups 47,48,49,50,51,52,53,54,55,56.Among those ...

This video shows a fleeting hemiacetal alkoxide intermediate, which the researchers, unprecedentedly, captured. The team also observed its reverse aldehyde elimination, generating an aldehyde ...