In conclusion, this study shows that S1pr3 contributes to PF by modulating macrophage M2 polarization through the PI3K/Akt-Stat3 signaling pathway. In addition, S1pr3 inhibitors were effective ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...