MMF at a dose of 0.5–2 g daily has been effective at inducing a partial response or complete remission in 39–84% of autoimmune hepatitis patients who did not respond to conventional therapy.

Whether or not to treat asymptomatic AIH remains unclear--therapy with immunosuppressants could potentially slow progress of the disease but involves side effects that are sometimes toxic.

Approximately 10–20% of AIH patients are initially seronegative for the conventional autoantibodies, which may appear after immunosuppressive therapy is begun. pANCA testing may be helpful in ...

The treatment of autoimmune hepatitis is evolving as the pathogenic pathways that underlie the disease are defined, new immunosuppressive agents are tested, and site-specific molecular ...

AIH is associated with inflammation (swelling ... Likewise, there are studies on natural killer cell therapy, wherein the cells through their anti-viral, liver protective, and regenerative ...

AIH in pregnant women and elderly patients poses unique challenges. Maintenance therapy with low-dose predniso(lo)ne and AZA is recommended during pregnancy to reduce relapse risk. For the elderly ...

It remains important to distinguish autoimmune hepatitis from other forms of chronic hepatitis, because a high percentage of cases respond to antiinflammatory or immunosuppressive therapy ...

AIH is diagnosed on the basis of biochemical and serological tests along with histologic examination of the liver. 1,2 Optimal therapy is challenging when AIH is accompanied by chronic hepatitis C, as ...

“A deeper understanding of HRQOL is therefore essential if we are to make progress with therapy in AIH.” To explore the impact of AIH and its treatment on patient life quality, the researchers ...

In relapsed, steroid-dependent AIH patients, of the 21 of 24 entering screening on steroid-based therapy, 36% (5 of 14) of zetomipzomib-treated patients achieved a complete biochemical response ...

“Clinicians treating patients with AIH may consider mycophenolate mofetil as a potential first-line therapy, particularly for patients who are intolerant or have had adverse reactions to ...

The data discussed earlier indicate that MMF may have value as an alternative treatment for AIH patients who do not respond to standard treatment. However, more data are required. Randomized ...